Cheol-Soo Choi
Endocrinology Cheol-Soo Choi Favorite Doctor
  • SpecialtyObesity, Diabetes mellitus, Dyslipidemia, Thyroid diseases
  • Site
의료진 진료일정
Week M T W T F S
AM     Present      
Clinical Interests

Diabetes mellitus
Thyroid diseases

1999 Pusan National University School of Medicine, Ph.D.
1993 Pusan National University School of Medicine, M.S.
1987 Pusan National University School of Medicine, M.D.
2010~ Director of NECMD(National Efficacy Evaluation Center for Metabolic Diseases Therapeutics)
2007~ Director of KMMPC(Korea Mouse Metabolic Phenotyping Center)
2007~ Department of Endocrinology, Gachon University Gil Medical Center, Professor
2007~ Molecular Medicine, Gachon University College of Medicine, Professor
2013 Minister of Health and Welfare Award, Merit of Health and Medical Service Technology Promotion
2014 Director of R&D Center, Gachon University Gil Medical Center
2002 Hallym University College of Medicine, Associate Professor
2000 Hallym University College of Medicine, Assistant Professor
1995 Department of Endocrinology, Asan Medical Center, Fellow
1991 Pusan National University Hospital, Resident
1988 Public Health Doctor
1987 Pusan National University Hospital, Intern
2005 Yale university School of Medicine Co-Director of the In Vivo Metabolism Core of Yale MMPC
2005 Yale university School of Medicine Associate Research Scientist/Scholar
2003 Yale university School of Medicine Research Associate
1997 University of Southern California, USA
1997 Endocrinology Specialist
1995 Internal Medicine Specialist
1993 Special License for Radioisotope Operation
1987 Medical License
Cheol-Soo Choi
2022 Mi-Ock Baek, Hye-jeong Cho, Do Sik Min, Cheol Soo Choi* & Mee-Sup Yoon*. Self-transducible LRS-UNE-L peptide enhances muscle regeneration Journal of Cachexia, Sarcopenia and Muscle. 13(2):1277-1288
2022 Kim Y, Park S, Lee J, Jang J, Jung J, Koh JH, Choi CS, Wolfe RR, Kim IY. Essential Amino Acid-Enriched Diet Alleviates Dexamethasone-Induced Loss of Muscle Mass and Function through Stimulation of Myofibrillar Protein Synthesis and Improves Glucose Metabolism in Mice. Metabolites. 12(1):84
2022 Um JH, Park SY, Hur JH, Lee HY, Jeong KH, Cho Y, Lee SH, Yoon SM, Choe S, Choi CS. Bone morphogenic protein 9 is a novel thermogenic hepatokine secreted in response to cold exposure. Metabolism. 129:155139
2022 Shin-Hae Lee, Shi-Young Park, Cheol Soo Choi. Insulin resistance: from mechanisms to therapeutic strategies. Diabetes Metab J. 46(1):15-37
2021 Kalu K. Asanka Sanjeewa, Kalahe H. N. M. Herath , Hye-Won Yang, Cheol Soo Choi*, and You-Jin Jeon*. Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review. Mar. Drugs 19(12):678
2021 Kim A, Koo JH, Jin X, Kim W, Park SY, Park S, Rhee EP, Choi CS, Kim SG. Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes. J Cachexia Sarcopenia Muscle. 12(6):1669-1689
2021 Jang J, Park S, Kim Y, Jung J, Lee J, Chang Y, Lee SP, Park BC, Wolfe RR, Choi CS*, Kim IY*. Myostatin Inhibition-Induced Increase in Muscle Mass and Strength Was Amplified by Resistance Exercise Training, and Dietary Essential Amino Acids Improved Muscle Quality in Mice. Nutrients. 13(5):1508
2021 Kim J, Kim SH, Kang H, Lee S, Park SY, Cho Y, Lim YM, Ahn JW, Kim YH, Chung S, Choi CS, Jang YJ, Park HS, Heo Y, Kim KH, Lee MS. TFEB-GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response. Nat Metab. 3(3):410-427
2021 Kang GM, Min SH, Lee CH, Kim JY, Lim HS, Choi MJ, Jung SB, Park JW, Kim S, Park CB, Dugu H, Choi JH, Jang WH, Park SE, Cho YM, Kim JG, Kim KG, Choi CS, Kim YB, Lee C, Shong M, Kim MS. Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism. Cell Metab. 33(2):334-349
2021 Mok J, Park TS, Kim S, Kim D, Choi CS, Park J. Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle. FASEB J. 35(2):e21179
2021 Choi SJ, Kim SM, Kim YS, Kwon OS, Shin SK, Kim KK, Lee K, Park IB, Choi CS, Chung DH, Jung J, Paek M, Lee DH. Magnetic Resonance-Based Assessments Better Capture Pathophysiologic Profiles and Progression in Nonalcoholic Fatty Liver Disease. Diabetes Metab J. 45(5):739-752
2020 Kim IY, Park S, Kim Y, Chang Y, Choi CS, Suh SH, Wolfe RR.In Vivo and In Vitro Quantification of Glucose Kinetics: From Bedside to Bench.. Endocrinol Metab. 35(4):733-749
2020 Won-Chul Lee, N.G. Gurudatt, Deog-Su Park, Kwang Bok Kim, Cheol Soo Choi*, Yoon-Bo Shim*. Microneedle array sensor for monitoring glucose in single cell using glucose oxidase-bonded polyterthiophene coated on AuZn oxide layer. Sensors and Actuators B: Chemical 320: 128416
2020 Kim J, Kim H, Noh SH, Jang DG, Park SY, Min D, Kim H, Kweon HS, Kim H, Aum S, Seo S, Choi CS, Kim H, Kim JW, Moon SJ, Gee HY, Lee MG. Grasp55-/- mice display impaired fat absorption and resistance to high-fat diet-induced obesity. Nat Commun. 11(1):1418
2020 Park H, Jang HR, Park S, Kim Y, Lee H, Choi CS. The essential role of fructose-1,6-bisphosphatase 2 enzyme in thermal homeostasis upon cold stress. 52(3):485-496. Exp Mol Med 52(3):485-496
2020 Shin JH, Lee G, Jeong MG, Kim HK, Won HY, Choi Y, Lee JH, Nam M, Choi CS, Hwang GS, Hwang ES. Transcriptional coactivator with PDZ-binding motif suppresses the expression of steroidogenic enzymes by nuclear receptor 4 A1 in Leydig cells. FASEB J. 34(4):5332-5347
2020 Jung YS, Kim YH, Radhakrishnan K, Kim J, Kim DK, Lee JH, Oh H, Lee IK, Kim W, Cho SJ, Choi CS, Dooley S, Egan JM, Lee CH, Choi HS. An inverse agonist of estrogen-related receptor γ regulates 2-arachidonoylglycerol synthesis by modulating diacylglycerol lipase expression in alcohol-intoxicated mice. Arch Toxicol. 94(2):427-438
2020 Shin SK, Kim KO, Kim SH, Kwon OS, Choi CS, Jeong SH, Kim YS, Kim JH, Chung MH. Exogenous 8-hydroxydeoxyguanosine ameliorates liver fibrosis through the inhibition of Rac1-NADPH oxidase signaling. J Gastroenterol Hepatol. 35(6):1078-1087
2019 Kim TH, Koo JH, Heo MJ, Han CY, Kim YI, Park SY, Cho IJ, Lee CH, Choi CS, Lee JW, Kim W, Cho JY, Kim SG, Overproduction of inter-α-trypsin inhibitor heavy chain 1 after loss of Gα13 in liver exacerbates systemic insulin resistance in mice. Sci Transl Med. 11(513)
2019 Kim TH, Lee K, Park IB, Choi CS, Ahn TH, Lee DH. The effects of DPP4 inhibitors on the levels of plasma catecholamines and their metabolites in patients with type 2 diabetes. Diabetes Res Clin Pract. 156:107832
2019 Lee K, Park IB, Yu SH, Kim SK, Kim SH, Seo DH, Hong S, Jeon JY, Kim DJ, Kim SW, Choi CS, Lee DH. Characterization of variable presentations of diabetic ketoacidosis based on blood ketone levels and major society diagnostic criteria: a new view point on the assessment of diabetic ketoacidosis. Diabetes Metab Syndr Obes. 12:1161-1171
2019 Mozammal Hossain MD, Moon JM, Gurudatt NG, Park DS, Choi CS, Shim YB . Separation detection of hemoglobin and glycated hemoglobin fractions in blood using the electrochemical microfluidic channel with a conductive polymer composite sensor. Biosens Bioelectron. 142:111515
2019 Hong Y, Lee JH, Jeong KW, Choi CS, Jun HS. Amelioration of muscle wasting by glucagon-like peptide-1 receptor agonist in muscle atrophy. J Cachexia Sarcopenia Muscle. 10(4):903-918
2019 Lee WC, Kim KB, Gurudatt NG, Hussain KK, Choi CS, Park DS, Shim YB.Comparison of enzymatic and non-enzymatic glucose sensors based on hierarchical Au-Ni alloy with conductive polymer. Biosens Bioelectron. 130:48-54
2019 Park JG, Mok JS, Han YI, Park TS, Kang KW, Choi CS, Park HD, Park J.Connectivity mapping of angiotensin-PPAR interactions involved in the amelioration of non-alcoholic steatohepatitis by Telmisartan. Sci Rep. 9(1):4003
2018 Kim TH, Yang YM, Han CY, Koo JH, Oh H, Kim SS, You BH, Choi YH, Park TS, Lee CH, Kurose H, Noureddin M, Seki E, Wan YY, Choi CS, Kim SG. Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration. J Clin Invest. 128(12):5587-5602
2018 Eun-Hui Lee, Michal Itan, Jinsun Jang, Hyeon-Jung Gu, Perri Rozenberg, Melissa Mingler, Ting Wen, Jiyoung Yoon, Shi-Young Park, Joo Young Roh, Cheol Soo Choi, Woo-Jae park, Ariel Munitz, and YunJae Jung. Eosinophils support adipocyte maturation and promote glucose tolerance in obesity. Sci Rep. 8(1):98945094
2018 Murata K, Morino K, Ida S, Ohashi N, Lemecha M, Park SY, Ishikado A, Kume S, Choi CS, Sekine O, Ugi S, Maegawa H. Lack of O-GlcNAcylation enhances exercise-dependent glucose utilization potentially through AMP-activated protein kinase activation in skeletal muscle. Biochem Biophys Res Commun. 495(2):2098-2104
2017 Kang JK, Kim OH, Hur J, Yu SH1, Lamichhane S, Lee JW, Ojha U, Hong JH, Lee CS, Cha JY, Lee YJ, Lm SS, Park YJ, Choi CS, Lee DH, Lee IK, Oh BC. increased intracellular Ca2+ concentrations prevent membrane localization of PH domains through the formation of Ca2+-phosphoinositides. Proc Natl Acad Sci U S A. 114(45):11926-11931
2017 Koo JH, Kim TH1, Park SY2, Joo MS, Han CY, Choi CS, Kim SG. Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism. J Clin Invest. 127(10):3845-3860
2017 Lee SY, Lee HY, Song JH, Jeon S, Song YJ, Lee JS, Hur JH, OH HH, Park SY, Shim SM, Yoo HJ Lee BC, Jiang XC, Choi CS*, Park TS* Adipocyte-specific deficiency of de novo sphingolipid biosynthesis leads to lipodystrophy and insulin resistance Diabetes 66(10):2596-2609
2017 Ohashi N, Morino K, Ida S, Sekine O, Lemecha M, Kume S, Park SY, Choi CS, Ugi S, Maegawa H. Pivotal Role of O-GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis. Diabetes. 66(9):2351-2362
2017 Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation. Lee HY, Lee JS, Alves T, Ladiges W, Rabinovitch PS, Jurczak MJ, Choi CS, Shulman GI, Samuel VT.Diabetes. 2017 2072-2081
2017 Buddolla Viswanath, Cheol Soo Choi Kiyoung Lee Sanghyo Kim, Recent trends in the development of diagnostic tools for diabetes mellitus using patient saliva. Trends in Analytical Chemistry 89:60-67
2017 Cho J, Zhang Y, Park SY, Joseph AM, Han C, Park HJ, Kalavalapalli S, Chun SK, Morgan D, Kim JS, Someya S, Mathews CE, Lee YJ, Wohlgemuth SE, Sunny NE, Lee HY, Choi CS, Shiratsuchi T, Oh SP, Terada N. Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance. Nat Commun. 8:14477
2017 Kim DM, Moon JM, Lee WC, Yoon JH, Choi CS, Shim YB. A potentiometric non-enzymatic glucose sensor using a molecularly imprinted layer bonded on a conducting polymer. Biosens Bioelectron. 91:276-283
2016 Hur JH, Park SY, Dall'Armi C, Lee JS, Di Paolo G, Lee HY, Yoon MS, Min DS, Choi CS. Phospholipase D1 deficiency in mice causes nonalcoholic fatty liver disease via an autophagy defect. Sci Rep. 6:39170
2016 Han SJ, Choi SE, Yi SA, Jung JG, Jung IR, Shin M, Kang S, Oh H, Kim HJ, Kim DJ, Kwon JE, Choi CS*, Lee KW*, Kang Y*. Glutamate dehydrogenase activator BCH stimulating reductive amination prevents high fat/high fructose diet-induced steatohepatitis and hyperglycemia in C57BL/6J mice. Sci Rep. 5:37468
2016 Oh YT, Oh HH, Nguyen AK, Choi CS, Youn JH. Circulating free fatty acids inhibit food intake in an oleate-specific manner in rats. Physiol Behav. 167:194-201
2016 Mee-Sup Yoon, Cheol Soo Choi. The role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistance. Experimental & Molecular Medicine 48(1): e201
2016 Go Y, Jeong JY, Jeoung NH, Jeon JH, Park BY, Kang HJ, Ha CM, Choi YK, Lee SJ, Ham HJ, Kim BG, Park KG, Park SY, Lee CH, Choi CS, Park TS, Lee WN, Harris RA, Lee IK. Inhibition of pyruvate dehydrogenase kinase 2 protects against hepatic steatosis through modulation of TCA cycle anaplerosis and ketogenesis. Diabetes, Diabetes. 65(10):2876-87
2015 Devadhasan JP, Oh H, Choi CS, Kim S. Whole blood glucose analysis based on smartphone camera module. J Biomed Opt. 20(11):117001, 2015. (IF 2.859)
2015 Oh H, Jeong KH, Han HY, Son HJ, Kim SS, Lee HJ, Kim S, Sa JH, Jun HS, Ryu JH, Choi CS. A potent and selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, SKI2852, ameliorates metabolic syndrome in diabetic mice models. Eur J Pharmacol. 768:139-48, 2015 (IF 2.532)
2015 Shin JH, Kim IY, Kim YN, Shin SM, Roh KJ, Lee SH, Sohn M, Cho SY, Lee SH, Ko CY, Kim HS, Choi CS, Bae YS, Seong JK. Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak-/- Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure. PLoS One. 10(12):e0144478, 2015 (IF 3.234)
2015 Choi Y, Kwon Y, Kim DK, Jeon J, Jang SC, Wang T, Ban M, Kim MH, Jeon SG, Kim MS, Choi CS, Jee YK, Gho YS, Ryu SH, Kim YK. Gut microbe-derived extracellular vesicles induce insulin resistance, thereby impairing glucose metabolism in skeletal muscle. Sci Rep. 5:15878, 2015 (IF 5.578)
2015 Oh YS, Shin S, Li HY, Park EY, Lee SM, Choi CS, Lim Y, Jung HS, Jun HS. Betacellulin ameliorates hyperglycemia in obese diabetic db/db mice. J Mol Med (Berl). 93:1235-1245, 2015 (IF 5.107)
2015 Mir TA, Akhtar MH, Gurudatt NG, Kim JI, Choi CS, Shim YB. An amperometric nanobiosensor for the selective detection of K+-induced dopamine released from living cells. Biosens Bioelectron. 68:421-428, 2015 (IF 6.451)
2015 Lee YS, Kim D, Lee EK, Kim S, Choi CS, Jun HS. Sodium meta-arsenite prevents the development of autoimmune diabetes in NOD mice. Toxicol Appl Pharmacol. 284(2):254-61, 2015 (IF 3.630)
2015 Jong-Hee Hwang, Cheol Soo Choi. In vivo Magnetic Resonance Spectroscopy (MRS) for Studying Metabolic Diseases. Exp Mol Med 47:e139, 2015
2014 Linkang Zhou, Shi-Young Park, Li Xu, Xiayu Xia, Jing Ye, Kyeong-Hoon Jeong, Jang Ho Hur, Hyunhee Oh, Yoshikazu Tamori, Cristina M. Zingaretti, Saverio Cinti, Jesús Argente, Miao Yu, Lu Su, Lizhen Wu, Shenghong Ju, Feifei Guan, Hongyuan Yang, Cheol Soo Choi*, David B. Savage*, Peng Li* Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice. Nat. Commun. 6:5949, 2015 * contributed equally (IF 10.742)
2014 Lee YS, Lee EK, Oh HH, Choi CS, Kim S, Jun HS. Sodium Meta-Arsenite Ameliorates Hyperglycemia in Obese Diabetic db/db Mice by Inhibition of Hepatic Gluconeogenesis. J Diabetes Res. 2014:961732, 2014. (IF 2.164)
2014 Shim KH1, Jeong KH2, Bae SO1, Kang MO1, Maeng EH3, Choi CS2, Kim YR4, Hulme J1, Lee EK1, Kim MK4, An SS1. Assessment of ZnO and SiO2 nanoparticle permeability through and toxicity to the blood-brain barrier using Evans blue and TEM. Int J Nanomedicine. 9 Suppl 2:225-33. eCollection 2014. (IF 4.383)
2014 Kibbey RG, Choi CS, Lee HY2, Cabrera O, Pongratz RL, Zhao X, Birkenfeld AL, Li C, Berggren PO, Stanley C, Shulman GI. Mitochondrial GTP insensitivity contributes to hypoglycemia in Hyperinsulinemia Hyperammonemia (HI/HA) by inhibiting glucagon release. Diabetes. 63(12):4218-29, 2014 (IF 8.474)
2014 Lee HY, Jeong KH, Choi CS. In-depth metabolic phenotyping of genetically engineered mouse models in obesity and diabetes. Mamm Genome. 25(9-10):508-521, 2014 (IF 2.883)
2014 Lee HY, Gattu AK, Camporez JP, Kanda S, Guigni B, Kahn M, Zhang D, Galbo T, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Choi CS, Yan Z, Williams RS, Shulman GI, Samuel VT. Muscle-specific activation of Ca2+/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. Diabetologia. 57(6):1232-41, 2014 (IF 6.880)
2014 Lee EY, Kim YW, Oh H, Choi CS, Ahn JH, Lee BW, Kang ES, Cha BS, Lee HC. Anti-obesity effects of KR-66195, a synthetic DPP-IV inhibitor, in diet-induced obese mice and obese-diabetic ob/ob mice.Metabolism 63(6):793-9, 2014 (IF 3.096)
2014 Giménez-Cassina A*, Garcia-Haro L*, Choi CS*, Osundiji MA, Lane EA, Huang H, Yildirim MA, Szlyk B, Fisher JK, Polak K, Patton E, Wiwczar J, Godes M, Lee DH, Robertson K, Kim S, Kulkarni A, Distefano A, Samuel V, Cline G, Kim YB, Shulman GI, Danial NN. Regulation of hepatic energy metabolism and gluconeogenesis by BAD. Cell Metab. 19(2):272-84, 2014 * contributed equally (IF 14.619)
2014 Yi JS, Park JS, Ham YM, Nguyen N, Lee NR, Hong J, Kim BW, Lee H, Lee CS, Jeong BC, Kyu Song H, Cho H, Kim YK, Lee JS, Park KS, Shin H, Choi I, Lee SH, Park WJ, Park SY, Choi CS, Lin P, Karunasiri M, Tan T, Duann P, Zhu H, Ma J, Ko YG. MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling. Nat Commun. 4:2354, 2013 (IF 10.015)
2013 Moon HY, Song P, Choi CS, Ryu SH, Suh PG. Involvement of exercise-induced macrophage migration inhibitory factor in the prevention of fatty liver disease. J Endocrinol. 218(3):339-48, 2013 (IF 4.058)
2013 Kim DK, Gang GT, Ryu D, Koh M, Kim YN, Kim SS, Park J, Kim YH, Sim T, Lee IK, Choi CS, Park SB, Lee CH, Koo SH, Choi HS. Inverse Agonist of Nuclear Receptor ERRγ Mediates Antidiabetic Effect Through Inhibition of Hepatic Gluconeogenesis. Diabetes. 62(9):3093-102,2013 (IF 7.895)
2013 Park M, Wu D, Park T, Choi CS, Li R, Cheng KK, Xu A, Sweeney G. APPL1 transgenic mice are protected from high fat diet induced cardiac dysfunction. Am J Physiol Endocrinol Metab. 305(7):E795-804, 2013 (IF 4.514)
2013 Devadhasan JP, Kim S, Choi CS. CMOS image sensors as an efficient platform for glucose monitoring.Analyst. 138(19):5679-84, 2013 (IF 3.969)
2013 Löffler MG, Birkenfeld AL, Philbrick KM, Belman JP, Habtemichael EN, Booth CJ, Castorena CM, Choi CS, Jornayvaz FR, Gassaway BM, Lee HY, Cartee GD, Philbrick W, Shulman GI, Samuel VT, Bogan JS. Enhanced Fasting Glucose Turnover in Mice with Disrupted Action of TUG Protein in Skeletal Muscle. J Biol Chem. 288(28):20135-50, 2013 (IF 4.651)
2013 Kim KH, Jeong YT, Oh H, Kim S, Cho JM, Kim Y, Kim SS, Kim DH, Hur KY, Kim HK, Ko TH, Han J, Kim HL, Kim J, Back SH, Komatsu M, Chen H, Chan DC, Konishi M, Itoh1N, Choi CS* & Lee M*. Autophage deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a ‘mitokine’. Nat Medicine 19:83-93, 2013 (IF 22.462) * contributed equally
2013 Lee KM, Yang SJ, Kim YD, Choi YD, Nam JH, Choi CS, Choi HS, Park CS. Disruption of the cereblon gene enhances hepatic AMPK activity and prevents high fat diet-induced obesity and insulin resistance in mice. Diabetes. 2013 Jan 24. (IF 8.286)
2013 Huh JY, Kim JI, Park YJ, Hwang IJ, Lee YS, Sohn JH, Lee SK, Alfadda AA, Kim SS, Choi SH, Lee DS, Park SH, Seong RH, Choi CS, Kim JB.A Novel Function of Adipocytes in Lipid Antigen Presentation to iNKT Cells. Mol Cell Biol. 33(2):328-39, 2013 (IF 7.667)
2012 Oh KJ, Park J, Kim SS, Oh H, Choi CS, Koo SH. TCF7L2 Modulates Glucose Homeostasis by Regulating CREB- and FoxO1-Dependent Transcriptional Pathway in the Liver. PLoS Genet. 8(9):e1002986, 2012 (IF 8.694)
2012 Lee YS, Park MS, Choung JS, Kim SS, Oh HH, Choi CS, Ha SY, Kang Y, Kim Y, Jun HS. Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes. Diabetologia. 55(9):2456-68, 2012 (IF 6.814)
2012 Choi CS, Kim MY, Han K, Lee MS. Assessment of β-cell function in human patients. Islets 4(2):79-83, 2012 (IF 1.123)
2012 Lee SY, Kim JR, Hu Y, Khan R, Kim SJ, Bharadwaj KG, Davidson MM, Choi CS, Shin KO, Lee YM, Park WJ, Park IS, Jiang XC, Goldberg IJ, Park TS. Cardiomyocyte specific deficiency of serine palmitoyltransferase subunit 2 reduces ceramide but leads to cardiac dysfunction. J Biol Chem. 287(22):18429-39, 2012 (IF 4.773)
2012 Morino K, Petersen KF, Sono S, Choi CS, Samuel VT, Lin A, Gallo A, Zhao H, Kashiwagi A, Goldberg IJ, Wang H, Eckel RH, Maegawa H, Shulman GI. Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes. Diabetes. 61(4):877-87, 2012 (IF 8.286)
2012 Quan W, Kim HK, Moon EY, Kim SS, Choi CS, Komatsu M, Jeong YT, Lee MK, Kim KW, Kim MS, Lee MS. Role of Hypothalamic Proopiomelanocortin Neuron Autophagy in the Control of Appetite and Leptin Response. Endocrinology. 153(4):1817-26, 2012 (IF 4.459)
2012 Marimuthu M, Park C, Kim S, Choi CS. Real-time electrical measurement of L929 cellular spontaneous and synchronous oscillation. Int J Nanomedicine. 7:83-92, 2012 (IF 4.424)
2012 Liu W, Singh R, Choi CS, Hui-Young L, Keramati AR, Samuel VT, Lifton RP, Shulman GI, Mani A. LDL Receptor Related Protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure. J Biol Chem. 287(10):7213-23, 2012 (IF 4.773)
2012 Shinozaki S, Choi CS, Shimizu N, Yamada M, Kim M, Zhang T, Dong HH, Kim YB, Kaneki M. Liver-specific iNOS expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice. J Biol Chem. 286(40):34959-75, 2011 (IF 4.773)
2011 Lee HY, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Kanda S, Popov V, Frederick DW, Zhang D, Guigni B, Bharadwaj KG, Choi CS, Goldberg IJ, Park JH, Petersen KF, Samuel VT, Shulman GI. Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance. Hepatology. 7(12):4109-19, 2011 (IF 11.665)
2011 Shin HJ, Park YH, Kim SU, Moon HB, Park DS, Han YH, Lee CH, Lee DS, Song IS, Lee DH, Kim M, Kim NS, Kim DG, Kim JM, Kim SK, Kim YN, Kim SS, Choi CS, Kim YB, Yu DY. Hepatitis B virus X protein regulates hepatic glucose homeostasis via activation of inducible nitric oxide synthase. J Biol Chem. 286(34):29872-29881, 2011 (IF 4.773)
2011 Ryu D, Seo WY, Yoon YS, Kim YN, Kim SS, Kim HJ, Park TS, Choi CS*, Koo SH*. Endoplasmic Reticulum Stress Promotes LIPIN2-Dependent Hepatic Insulin Resistance. Diabetes, 2011 (IF 8.505) *contributed equally
2011 Chang ZQ, Lee SY, Kim HJ, Kim JR, Kim SJ, Hong IK, Oh BC, Choi CS, Goldberg IJ, Park TS. endotoxin activates de novo sphingolipid biosynthesis via nuclear factor kappa B-mediated upregulation of Sptlc2. Prostaglandins Other Lipid Mediat. 94(1-2):44-52, 2011 (IF 2.557)
2011 Jongin Hong, Karthikeyan Kandasamy, Mohana Marimuthu, Cheol Soo Choi and Sanghyo Kim. Electrical cell-substrate impedance sensing as a non-invasive tool for cancer cell study. Analyst 136(2), 237–245, 2011 (IF 4.230)
2010 Lee HY, Choi CS, Birkenfeld AL, Alves TC, Jornayvaz FR, Jurczak MJ, Zhang D, Woo DK, Shadel GS, Ladiges W, Rabinovitch PS, Santos JH, Petersen KF, Samuel VT, Shulman GI. Targeted expression of catalase to mitochondria prevents age- associated reductions in mitochondrial function and insulin resistance. Cell Metab. 12(6): 668-674, 2010 (IF 17.35)
2010 Choi CS, Ghoshal P, Srinivasan M, Kim S, Cline G, Patel MS. Liver-specific pyruvate dehydrogenase complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin sensitivity. Lipids 45(11): 987-995, 2010 (IF 2.382)
2010 Yoon YS, Lee MW, Ryu D, Kim JH, MA H, Seo WY, Kim YN, Kim SS, Lee CH, Hunter T, Choi CS, Montminy MR, Koo SH. Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis. Proc Natl Acad Sci USA, 107(41):17704-17709, 2010 (IF 9.432)
2010 Srinivasan M, Choi CS, Ghoshal P, Pliss L, Pandya JD, Hill DJ, Cline GW, Patel MS. Beta cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion. AM J Physiol Endocrinol Metab. 299(6): E910-917, 2010
2010 Zhang D, Christianson J, Liu ZX, Tian L, Choi CS, Neschen S, Dong J, Wood PA, Shulman GI. Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency. Cell Metab. 115(5): 402-411, 2010 (IF 17.35)
2010 Lee MW, Chanda D, Yang J, Oh H, Kim SS, Yoon YS, Hong S, Park KG, Lee IK, Choi CS, Hanson RW, Choi HS, Koo SH. Regulation of hepatic gluconeogenesis by an ER-bound transcription factor, CREBH. Cell metab. 11(4):331-3392010 (IF 17.35)
2010 Andrews ZB, Erion DM, Beiler R, Choi CS, Shulman GI, Horvath TL. Uncoupling Protein-2 Decreases the Lipogenic Actions of Gherlin. Endocrinology 151 (5):2078-2086, 2010 (IF 4.752)
2010 Won JC, Park JK, Kim YM, Koh EH, Seol S, Jeon BH, Han J, Kim JR, Park TS, Choi CS, Lee WJ, Kim MS, Lee IK, Youn JH, Lee KU. Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. Arterioscler Thromb vasc Biol. 30(2):290-7, 2010
2010 Kandasamy K, Choi CS, Kim S. An efficient analysis of nanomaterial cytotoxicity based on bioimpedance. Nanotechnology. 21(37):375501, 2010 (IF 3.979)
2009 Estall JL, Ruas JL, Choi CS, Laznik D Badman M, Maratos-Flier E, Shulman GI, Spiegelman BM. PGC-lalpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proc Natl Acad Sci USA, 106(52): 22510-22515, 2009 (IF 9.432)
2009 Liu L, Shi X, Choi CS, Shulman GI, Klaus K, Nari KS, Schwarts GJ, Zhang Y, Goldberg IJ, Yu YH. Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1. Diabetes 58:2516-2524, 2009 (IF 8.505)
2009 Ryu D, Oh KJ, Jo HY, Hedrick S, Kim YN, Hwang YJ, Park TS, Choi CS, Montminy M, Koo SH. TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1. Cell Metab. 9(2)240-251, 2009(IF 17.35)
2009 Rowe GC, Choi CS, Neff L, Horne WC, Shulman GI, Baron R. Increased energy expenditure and insulin sensitivity in the high bone mass {Delta}FosB transgenic mice. Endocrinology 150(1):135-143, 2009 (IF 4.752)
2009 Wang H, Knaub LA, Jensen DR, Jung DY, Hong EG, Ko HJ, Coates AM, Goldberg IJ, de la houssaye BA, Janssen RC, McCurdy CE, Rahman SM, Choi CS, Shulman GI, Kim JK, Kim JK, Friedman JE, Eckel RH. Skeletal Muscle-Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues. Diabetes 5(1): 116-124, 2009 (IF 8.398)
2009 Lee HJ, Lee YH, Park SK, KIM HJ, Lee YC, Choi CS, Park SE, Ahn CW, Cha BS, Lee KW, Kim KS, Lim SK, Lee HC. Korean red ginseng(Panaz ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushinma fatty rats. Metabolism 58(8):1170-1177, 2009
2008 Cheol Soo Choi, Roberto Codella, Doughlas E. Befroy, Sheene Kim, Richard M. Reznick, Yu-Jin Hwang, Zhen-Xiang Liu, Hui-Young Lee, Alberto Distefano, Varman T. Samuel, Dongyan Zhang, Gary W. Cline, Christoph Handschin, Jiandie Lin, Kitt F. Petersen, Bruce M. Spiegelman and Gerald I. Shulman. Paradoxical Effects of Increased Expression of PGC-1 ‧α on Muscle Mitochondrial Function and Insulin Stimulated Muscle Glucose Metabolism. Proc Natl Acad Sci USA, 150(50): 19926-19931, 2008 (IF 9.38)
2008 Matthew P. Gillum, Xian-Man Zhang, Dongyan Zhang, Derek M. Erion, Rachel A. Jamison, Cheolsoo Choi, Jianying Dong, Marya Shanabrough, Hillary R. Duenas, David W. Frederick, Jennifer J. Hsiao, Tamas L. Horvath, Katie Carey, Pat Tso, Gary W. Cline, Gerald I. Shulman. N-acylphosphatidylethanolamine, a gut-derived circulating factor induced by fat ingestion, inhibits food intake. Cell 135(5):813-824, 2008 (IF 31.253)
2008 Cheol Soo Choi*. Josep A. Villena*, Yuhui Wang, Sheene Kim, Yu-Jin Hwang, Young-Bum Kim, Gary Cline, Gerald Ⅰ. Shulman and Hei Sook Sul. Resistance to high fat diet-induced obesity but exacerbated insulin resistance in mice overepressing Pref-1: a new model of partial lipodystrophy. Diabetes 57(12)3258-66, 2008 (IF 8.398)
2008 M. Faadiel Essop, Heidi S. Camp, Cheol Soo Choi, Saumya Sharma, Ryan M. Fryer, Glenn A. Reinhart, Patrick H. Guthrie, Assia Bentebibl, Zeiwei Gu, Gerald I. Shulman Heinrich Taegtmeyer, Salih J. Wakil and Lutfi Abu-Elheiga . Reduced Heart Size and Increased Myocardial Fuel Substrate Oxidation in ACC2 Mutant Mice. Am J Physiol Heart Circ Physiol (IF 3.724)
2008 David B Savage, Lanmin Zhai, Balasubramanian Ravikumar, Cheol Soo Choi, Johanna E Snaar, Amanda C McGuire, Sung-Eun Wou, Gemma Medina-Gomez, Sheene Kim, Cheryl B Bock, Dyann M Segvich, Antonio Vidal-Puig, Nicholas J Wareham, Gerald I Shulman, Fredrik Karpe, Roy Taylor, Bartholomew A Pederson, Peter J Roach, Stephen O'Rahilly, and Anna A DePaoli-Roach. A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice. Plos Med 5(1), 2008 (IF 13.75)
2008 Nika N Danial, Loren D Walensky, Chen-Yu Zhang, Cheol Soo Choi, Jill K Fisher, Anthony J A Molina, Sandeep Robert Datta, Kenneth L Pitter, Gregory H Bird, Jakob D Wikstrom, Jude T Deeney, Kirsten Robertson, Joel Morash, Ameya Kulkarni, Susanne Neschen, Sheene Kim, Michael E Greenberg, Barbara E Corkey, Orian S Shirihai, Gerald I Shulman, Bradford B Lowell & Stanley J Korsmeyer. Dual Role of Pro-apoptotic BAD in Insulin Secretion and β-Cell Survival. Nat Medicine 14: 144-153, 2008 (IF 25.6)
2007 Cheol Soo Choi, David Savage, Lufti Abu-Elheiga, Zhen-Xiang Liu, Sheene Kim, Ameya Kulkarni, Alberto Distefano, Yu-Jin Hwang, Richard M. Reznick, Roberto Codella, Dongyan Zhang, Gary W. Cline, Salih J. Wakil, Gerald I. Shulman. Continuous fat oxidation in Acetyl-CoA carboxylase 2 mutant mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc Natl Acad Sci USA 104(42): 16480-16485, 2007 (IF 9.681)
2007 Cheol Soo Choi, Jonathan J. Fillmore, Jason K. Kim, Zhen-Xiang Liu, Sheene Kim, Ameya Kulkarni, Alberto Distefano, Yu-Jin Hwang, Mario Kahn, Yan Chen, Chunli Yu, Irene K. Moore, Richard M. Reznick, Takamasa Higashimori, Emily F. Collier, Gerald I. Shulman. Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance. J Clin Invest, 117:1995-2003, 2007 (IF 13.069)
2007 Dongyan Zhang, Zhen-Xiang Liu, Cheol Soo Choi,, , Liqun Tian,, Richard Kibbey, Jianying Dong, Gary W. Cline, Philip A. Wood, Gerald I. Shulman. Mitochondrial Dysfunction due to long-chain Acyl-CoA Dehydrogenase Deficiency Causes Hepatic Steatosis and Hepatic Insulin Resistance. PNAS. 104:17075-17080, 2007 (IF 9.6)
2007 Robert V. Farese, Mini P. Sajan, Hong Wang, Pengfei Li, Steven Mastorides, William R. Gower, Jr., Sonali Nimal, Cheol Soo Choi, Sheene Kim, Gerald I. Shulman, C. Ronald Kahn, Ursula Braun, and Michael Leitges. Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes. J Clin Invest, 117(8):2289-2301, 2007 (IF 15.8)
2007 Christoph Handschin, Cheol Soo Choi, Sherry Chin, Sheene Kim, Dan Kawamori, Amamath J. Kurpad, Nicole Neubauer, Jiang Hu, Fenfen Liu, Eleftheria Maratos-Flier, Vamsi K. Mootha, Young-Bum Kim, Rohit N. Kulkarni, Gerald I. Shulman, and Bruce M. Spiegelman. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1α knockout mice through skeletal muscle-pancreatic B cell cross-talk. J Clin invest 117(11):3463-3474, 2007 (IF 15.8)
2007 Cheol Soo Choi, David B. Savage, Ameya Kulkarni, Xing Xian Yu, Zhen-Xiang Liu, Katsutaro Morino, Sheene Kim, Alberto Distefano, Varman T. Samuel, Susanne Neschen, Dongyan Zhang, Amy Wang, Xian-Man Zhang, Mario Kahn,Gary W. Cline, Sanjay K. Pandey, John G. Geisler, Sanjay Bhanot, Brett P. Monia, Gerald I. Shulman. Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance. JBC , 282(31):22678-88, 2007 (IF 5.8)
2007 Qingchun Tong, ChianPing Ye, Rory J. McCrimmon, Harveen Dhillon, Brian Choi, Melissa Kramer, Jia Yu, Zongfang Yang Lauryn Christiansen, Siobhan kowronek, Charlotte Lee, Cheol Soo Choi, Jeffrey M. Zigman, Gerald I. Shulman, Robert Sherwin, Joel K. Elmquist and Bradford B. Lowell1. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab. 5(5):383-393, 2007 (IF 16.7)
2007 Jonathan B. Hurov, Mei huang, Lynn S. White, Cheol Soo Choi, You-Ree Cho, Hyo-Jeong Kim, Julie L. Prior, David Piwnica-Worms, Lewis C. Cantley, Jason K. Kim, Gerald I. Shulman and Helen Piwnica-Worms. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. PNAS, 104: 5680-5685, 2007 (IF 9.6)
2007 Qian Gao, Gabor Mezei, Yan Rao, Cheol Soo Choi, Ingo Bechmann, Csaba Leranth, Dominique Torran-Allerand, Catherine A. Priest, James L. Roberts, Xiao-Bing Gao, Charles Mobbs, Gerald I. Shulman, Sabrina Diano, and Tamas L. Horvath. Anorectic estrogen mimics leptin’s effect on the re-wiring of melanocortin cells and stat3 signaling in obese animals. Nat Medicine. 2007;13(1):89-94 (IF 25.6)
2006 Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Stefan K, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman G, Spiegelman B, Lowell BB. Hypomorhphic Mutation in PGC1 causes mitochondrial dysfunction and liver insulin resistance. Cell Metab. 2006, 4(6):453-64. (IF 16.7)
2006 Alon M. Chen, Bhawanjit K. Brar, Cheol Soo Choi, David Rousso, Joan M. Vaughan, Yael Kuperman, Shee Ne Kim, Cindy Donaldson, Sean M. Smith, Chien Li, Tim R. Nagy, Gerald I. Shulman, Kuo-Fen Lee, Wylie W. Vale. Urocortin 2 mediates glucose utilization and insulin sensitivity in skeletal muscle. PNAS, 103(44):16580-5, 2006 (IF 9.6)
2006 Wu JJ, Roth RJ, Anderson EJ, Hong E, Lee M, Choi CS, Neufer D, Shulman GI, Kim JK, Bennett AM: Mice Lacking Mitogen-Activated protein(MAP) Kinase Phosphatase-1 have Enhanced MAP Kinase Activity and Resistance to Diet-Induced Obesity. Cell Metabolism, 4(1):61-73, 2006. (IF 16.7)
2006 Cheol S. Choi*, Varman T. Samuel*, Trevor G. Phillips, Antony J. Romaneli, John G. Geisler, Sanjay Bhanot, Robert McKay, Brett Monia, John R. Shutter, Richard A. Lindberg, Gerald I. Shulman and Murielle M. Veniant: Targeting Foxo1 in mice using Antisense Oligonucleotide Improves Hepatic and Peripheral Insulin Action. Diabetes 55:2042-2050, 2006. * contributed equally (IF 7.9)
2006 Cheol S. Choi* , David B. Savage*, Varman T. Samuel, Zhen-Xiang Liu, Dongyan Zhang, Amy Wang, , Xian-Man Zhangi, Gary W. Cline, Xing Xian Yu, John G. Geisler, Sanjay Bhanot, Brett Monia, Gerald I.Shulman. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. Journal of Clinical Investigation 116(3):817-824, 2006 * contributed equally (IF 15.8)
2006 Stefan Bilz, Varman Samuel, Katsutaro Morino, David Savage, Cheol Soo Choi and Gerald I. Shulman: Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters. Am J Physiol Endocrinol Metab 290:E716-E722, 2006 (IF 4.5)
2005 Noboru Furukawa, Pat Ongusaha, Wan Jin Jahng, Kazushi Araki, Cheol S. Choi, Hyo-Jeong Kim, Kazushi Araki, Yong Hee Lee, Kozo Kaibuchi, Barbara B Kahn, Hiroaki Masuzaki, Jason K Kim, Sam W Lee and Young-Bum Kim: Role of Rho-kinase in Regulation of Insulin Action and Glucose Homeostasis. Cell Metabolism 2:119-129, 2005 (IF 16.7)
2005 Susanne Neschen, Katsutaro Morino, Linda E. Hammond, Dongyan Zhang, Anthony J. Romanelli, Gary W. Cline, Zhen-Xiang Liu, Cheol Soo Choi, Rosalind A. Coleman, and Gerald I. Shulman : Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knock out mice. Cell Metabolism 2:55-65, 2005 (IF 16.7)