Hyon Lee
(가천뇌건강센터) 신경과 Neurology Hyon Lee Favorite Doctor
  • SpecialtyDementia and Cognitive neurology
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Schedule / (가천뇌건강센터) 신경과
의료진 진료일정
Week M T W T F S
Schedule / Neurology
의료진 진료일정
Week M T W T F S
PM         Absent  
Clinical Interests

Dementia(Alzheimer's disease, vascular dementia, frontotemporal dementia)
Degenerative diseases
Memory disorders
Cognitive decline
Speech disorder
General neurological diseases

Seoul National University College of Medicine, M.S.
Yonsei University College of Medicine, M.D.
Molecular and Cell Biology, Neurobiology, University of California, Berkeley, B.S.
Director of International Healthcare Center, Gachon University Gil Medical Center
Gachon University Gil Medical Center, Assistant Professor
Gachon University Gil Medical Center, Clinical Assistant Professor
Department of Neurology, Seoul National University Hospital, Fellowship
Department of Neurology, Seoul National University Hospital, Residency
Yonsei University Severance Hospital, Intern
Harvard Medical School, Beth Israel Deaconess Medical Center
License of Medical Doctor
Neurology, Specialist
Hyon Lee
2020 Pathogenic PSEN1 Thr119Ile Mutation in Two Korean Patients with Early-Onset Alzheimer's Disease. Bagyinszky E, Lee H*, Pyun JM, Suh J, Kang MJ, Vo VG, An SSA, Park KH, Kim S. Diagnostics (Basel). 2020 Jun 14;10(6):405. doi: 10.3390/diagnostics10060405
2020 [¹⁸F]THK5351 PET Imaging in Patients with Mild Cognitive Impairment. J Clin Neurol. Jeong HJ, Lee H*, Lee SY, Seo S, Park KH, Lee YB, Shin DJ, Kang JM, Yeon BK, Kang SG, Cho J, Seong JK, Okamura N, Villemagne VL, Na DL, Noh Y. 2020 Apr;16(2):202-214. doi: 10.3988/jcn.2020.16.2.202.
2019 Relationships between [¹⁸F]-THK5351 Retention and Language Functions in Primary Progressive Aphasia. Jeong HJ, Yoon CW, Seo S, Lee SY, Suh MK, Seo HE, Kim WR, Lee H, Heo JH, Lee YB, Park KH, Choi SH, Ido T, Lee KM, Noh Y. J Clin Neurol. 2019 Oct;15(4):527-536. doi: 10.3988/jcn.2019.15.4.527.
2019 Role of POMC and AgRP neuronal activities on glycaemia in mice. Sci Rep. Üner AG, Keçik O, Quaresma PGF, De Araujo TM, Lee H, Li W, Kim HJ, Chung M, Bjørbæk C, Kim YB. 2019 Sep 10;9(1):13068. doi: 10.1038/s41598-019-49295-7.
2018 Glucose Hypometabolism in Hippocampal Subdivisions in Alzheimer's Disease: A Pilot Study Using High-Resolution ¹⁸F-FDG PET and 7.0-T MRI. Choi EJ, Son YD, Noh Y, Lee H, Kim YB, Park KH. J Clin Neurol. 2018 Apr;14(2):158-164. doi: 10.3988/jcn.2018.14.2.158.
2018 Genome-editing applications of CRISPR-Cas9 to promote in vitro studies of Alzheimer's disease. Giau VV*, Lee H*, Shim KH, Bagyinszky E, An SSA. Clin Interv Aging. 2018 Feb 7;13:221-233. doi: 10.2147/CIA.S155145. eCollection 2018. Review.
2017 Age-Related Changes in Nuclear Factor Erythroid 2-Related Factor 2 and Reactive Oxygen Species and Mitochondrial Structure in the Tongues of Fischer 344 Rats. Baek MK, Lee H, Kim KO, Kwon HJ, Chung MH, Park HM, Woo JH, Kim DY. Clin Exp Otorhinolaryngol. 2017 Dec; 10(4): 357–362.
2017 [18F]-THK5351 PET Imaging in Patients With Semantic Variant Primary Progressive Aphasia. Lee H, Seo S, Lee SY, Jeong HJ, Woo SH, Lee KM, Lee YB, Park KH, Heo JH, Yoon CW, Kang JM, Cho J, Okamura N, Furumoto S, Yanai K, Na DL, Ido T, Villemagne VL, Noh Y. Alzheimer Dis Assoc Disord. 2017 Oct 12. doi: 10.1097/WAD.0000000000000216.
2017 Tau positron emission tomography using [18F]THK5351 and cerebral glucose hypometabolism in Alzheimer's disease. Kang JM, Lee SY, Seo S, Jeong HJ, Woo SH, Lee H, Lee YB, Yeon BK, Shin DH, Park KH, Kang H, Okamura N, Furumoto S, Yanai K, Villemagne VL, Seong JK, Na DL, Ido T, Cho J, Lee KM, Noh Y. Neurobiol Aging. 2017 Aug 12. pii: S0197-4580(17)30263-4. doi: 10.1016/j.neurobiolaging.2017.08.008. [Epub ahead of print]
2016 Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood. Lee SH, Zabolotny JM, Huang H, Lee H, Kim YB. Mol Metab. 2016 Jun 29;5(8):589-601. doi: 10.1016/j.molmet.2016.06.011. eCollection 2016 Aug. Review.
2015 Development-assistance Strategies for Stroke in Low- and Middle-income Countries. Lee H, Nam YS, Lee KM. J Korean Med Sci. 2015 Nov;30 Suppl 2:S139-42. doi: 10.3346/jkms.2015.30.S2.S139. Epub 2015 Nov 6. Review.
2015 Low-frequency oscillations in cerebrovascular and cardiovascular hemodynamics: Their interrelationships and the effect of age. Song S, Kim D, Jang DP, Lee J, Lee H, Lee KM, Kim IY. Microvasc Res. 2015 Nov;102:46-53. doi: 10.1016/j.mvr.2015.08.004. Epub 2015 Aug 13.
2015 Early cognitive function tests predict early progression in glioblastoma. Lee ST, Park CK, Kim JW, Park MJ, Lee H, Lim JA, Choi SH, Kim TM, Lee SH, Park SH, Kim IH, Lee KM. Neuro-Oncology Practice 2015; 0, 1–7, doi:10.1093/nop/npv007.
2014 A case of Parkin disease (PARK2) with schizophrenia: Evidence of regional selectivity. Kim TJ, Kim TJ, Lee H, Kim YE, Jeon BS. Clin Neurol Neurosurg. 2014 Nov;126:35-7. doi: 10.1016/j.clineuro.2014.07.034. Epub 2014 Aug 20.
2014 Cystatin C, a novel indicator of renal function, reflects severity of cerebral microbleeds. Oh MY, Lee H, Kim JS, Ryu WS, Lee SH, Ko SB, Kim C, Kim CH, Yoon BW. BMC Neurol. 2014 Jun 12;14:127. doi: 10.1186/1471-2377-14-127.
2014 High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice. Kook SY, Lee KM, Kim Y, Cha MY, Kang S, Baik SH, Lee H, Park R, Mook-Jung I. Cell Death Dis. 2014 Feb 27;5:e1083. doi: 10.1038/cddis.2014.26.
2013 The possible role of antioxidant vitamin C in Alzheimer's disease treatment and prevention. Heo JH, Lee H, Lee KM. Am J Alzheimers Dis Other Demen. 2013 Mar;28(2):120-5.
2012 Change in prostaglandin expression levels and synthesizing activities in dry eye disease. Shim J, Park C, Lee HS, Park MS, Lim HT, Chauhan S, Dana R, Lee H, Lee HK. Ophthalmology. 2012 Nov;119(11):2211-9.
2010 Effect of stellate ganglion block on the cerebrovascular system: magnetic resonance angiography study. Kang CK, Oh ST, Chung RK, Lee H, Park CA, Kim YB, Yoo JH, Kim DY, Cho ZH. Anesthesiology. 2010 Oct;113(4):936-44.
2010 Activation of the stress protein response inhibits the STAT1 signalling pathway and iNOS function in alveolar macrophages: role of Hsp90 and Hsp70. Howard M, Roux J, Lee H, Miyazawa B, Lee JW, Gartland B, Howard AJ, Matthay MA, Carles M, Pittet JF. Thorax. 2010 Apr;65(4):346-53.
2010 Functional MR angiography using phase contrast imaging technique at 3T MRI. Kang CK, Kim SH, Lee H, Park CA, Kim YB, Cho ZH. Neuroimage. 2010 Apr 15;50(3):1036-43. Epub 2010 Jan 18.
2009 Hypertension correlates with lenticulostriate arteries visualized by 7T magnetic resonance angiography. Kang CK, Park CA, Lee H, Kim SH, Park CW, Kim YB, Cho ZH. Hypertension. 2009 Nov;54(5):1050-6. Epub 2009 Oct 5.
2005 Serum levels of Hsp60 correlate with the development of acute lung injury after trauma. Pespeni M, Mackersie RC, Lee H, Morabito D, Hodnett M, Howard M, Pittet JF. J Surg Res. 2005 Jun 1;126(1):41-7.
2005 Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90. Pittet JF*, Lee H*, Pespeni M, O'Mahony A, Roux J, Welch WJ. J Immunol. 2005 Jan 1;174(1):384-94.
2005 HO-1 induction restores c-AMP-dependent lung epithelial fluid transport following severe hemorrhage in rats. Lee H, Pespeni M, Roux J, Dennery PA, Matthay MA, Pittet JF. FASEB J. 2005 Feb;19(2):287-9. Epub 2004 Nov 18.
2003 High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance. Frank JA, Pittet JF, Lee H, Godzich M, Matthay MA. Am J Physiol Lung Cell Mol Physiol. 2003 May;284(5):L791-8. Epub 2003 Jan 31.
2002 Serum levels of Hsp 72 measured early after trauma correlate with survival. Pittet JF, Lee H, Morabito D, Howard MB, Welch WJ, Mackersie RC. J Trauma. 2002 Apr;52(4):611-7; discussion 617.
2002 Stress preconditioning attenuates oxidative injury to the alveolar epithelium of the lung following haemorrhage in rats. Pittet JF, Lu LN, Geiser T, Lee H, Matthay MA, Welch WJ. J Physiol. 2002 Jan 15;538(Pt 2):583-97
Other scholarship
2019 Rho-kinase mediates the anorexigenic action of melanocortin by suppressing AMPK. Kim SS, Hwang WM, Yang WM, Lee H, Park KD, Dagon Y, Kim YB. bioRxiv. 2019 Jun. doi: https://doi.org/10.1101/677880
2013 Transient contralateral tactile and auditory extinction after left thalamic hemorrhage. Lee H, Lim JS, Lee HS, Kwon HM. J Korean Neurol Assoc. 2013 Nov;31(4):273-276.
2003 Lee H, Godzich M, Pittet JF. “Heat Shock Response, Heat Shock Proteins, and Acute Lung Injury.” Lung Biology in Health and Disease: Acute Respiratory Distress Syndrome Vol 179, edited by Matthay MA, New York: Marcel Dekker, Inc, 2003, pp. 254-74.